Abstract Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and…
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types…
Abstract The genetic causes of cancer include both somatic mutations and inherited germline variants. Large-scale tumor sequencing has revolutionized the…
Abstract Electronic supplementary material: The online version of this article (doi:10.1186/s13059-016-0989-x) contains supplementary material, which is available to authorized users.…