The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Emil Spreitzer
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Abstract Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share…
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR…
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins
Abstract Electronic supplementary material: The online version of this article (10.1007/s10858-019-00248-2) contains supplementary material, which is available to authorized users.…