Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R
Abstract G protein-coupled receptors (GPCRs) are important therapeutic drug targets for a wide range of diseases. Upon activation, GPCRs can…
Eline J. Koers
A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay
Abstract Introduction: The kinetics of ligand binding to G protein-coupled receptors (GPCRs) is an important optimization parameter in drug discovery.…