Metabolomic profiling of cannabis use and cannabis intoxication in humans
Abstract Acute intoxication from Δ9-tetrahydrocannabinol (THC, the primary active ingredient of cannabis) can lead to neurocognitive impairment and interference with…
Eef L. Theunissen
Cannabis Use and Neuroadaptation: A Call for Δ9-Tetrahydrocannabinol Challenge Studies
Abstract Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function…
Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis
Abstract Background: Synthetic cannabinoids (SCs) are the largest class of novel psychoactive substances (NPS) and are associated with an increased…
Mephedrone and Alcohol Interactions in Humans
Abstract Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly…
Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users
Abstract Cannabis is the most commonly used illicit drug in the world. However, because of a changing legal landscape and…
Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders
Abstract Introduction: Synthetic cannabinoid mixtures have been easily accessible for years, leading to the belief that these products were natural…
Psychomotor Function in Chronic Daily Cannabis Smokers during Sustained Abstinence
Abstract Background: The present study assessed psychomotor function in chronic, daily cannabis smokers during 3 weeks continuously monitored abstinence on…
Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication
Abstract Rationale: Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. Objectives: The present study…
Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
Abstract Introduction: Previous research has shown that heavy cannabis users develop tolerance to the impairing effects of Δ9-tetrahydrocannabinol (THC) on…