Eberhard Schlicker

May 30, 2024

Re-evaluation of the cardioprotective effects of cannabinoids against ischemia-reperfusion injury according to the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria

Abstract Ischemic heart disease, associated with high morbidity and mortality, represents a major challenge for the development of drug-based strategies…

June 6, 2022

Cross-Talk between the (Endo)Cannabinoid and Renin-Angiotensin Systems: Basic Evidence and Potential Therapeutic Significance

Abstract This review is dedicated to the cross-talk between the (endo)cannabinoid and renin angiotensin systems (RAS). Activation of AT1 receptors…

March 28, 2022

Why Do Marijuana and Synthetic Cannabimimetics Induce Acute Myocardial Infarction in Healthy Young People?

Abstract The use of cannabis preparations has steadily increased. Although cannabis was traditionally assumed to only have mild vegetative side…

January 26, 2022

GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries

Abstract GPR18 receptor protein was detected in the heart and vasculature and appears to play a functional role in the…

February 17, 2021

Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19 †

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to coronavirus disease 2019 (COVID-19) which, in turn, may…

February 14, 2020

Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism

Abstract We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate (HR) in spontaneously (SHR) and…

May 22, 2019

Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

Abstract Cannabidiol (CBD) is a nonpsychotropic constituent of Cannabis sativa L. It is suggested to be useful in hypertension. Under…

April 14, 2018

Cannabinoids in arterial, pulmonary and portal hypertension – mechanisms of action and potential therapeutic significance

Authors: Barbara Malinowska ⚬, Marek Toczek, Anna Pędzińska‐Betiuk, Eberhard Schlicker Affiliations: Department of Experimental Physiology and Pathophysiology Medical University of…