Douglas McHugh

August 1, 2014

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

Abstract A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have…

January 2, 2014

Δ9-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18

Abstract Microglial cells are extremely plastic and undergo a variety of CNS-prompted shape changes relative to their location and current…

July 26, 2012

siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration

Abstract Background: Neurons are known to employ the endogenous cannabinoid system to communicate with other cells of the CNS. Endocannabioid…

March 26, 2010

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Abstract Background: Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that…