1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH
Abstract ITCH (aka Atrophin-1-interacting protein 4) is a prominent member of the NEDD4 HECT (Homologous to E6AP C-Terminus) E3 ubiquitin…
Donald E. Spratt
Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*
Abstract Background: Rbx1/ROC1 is an E3 ligase adaptor protein that functions with the E2 enzyme CDC34. Results: NMR and biochemical…