Prognostic and Immunological Significance of NMNAT1 in Colorectal and Pan-Cancer Contexts
Abstract Introduction: Nicotinamide plays a critical role in the prevention and treatment of tumors, and its metabolism is closely associated…
Deping Wang
Identification and validation of a novel prognostic signature and key genes related to development of anaplastic thyroid carcinoma
Abstract Background: Anaplastic thyroid carcinoma (ATC) is a rare but the most aggressive type of thyroid carcinoma. Nevertheless, limited advances…
Personalized tumor combination therapy optimization using the single-cell transcriptome
Abstract Background: The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for…
Cannabinoids function in defense against chewing herbivores in Cannabis sativa L.
Abstract In the decades since the first cannabinoids were identified by scientists, research has focused almost exclusively on the function…
Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display
Abstract Carbonic anhydrase (CA)-IX is an extracellular enzyme that is essential in the adaptation of tumor cells to their increasingly…
Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study
Abstract With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have…
Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor
Abstract Ligand-activated signaling through the type 1 insulin-like growth factor receptor (IGF1R) is implicated in many physiological processes ranging from…
Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures
Abstract There can be a fine line between therapeutic intervention and substance abuse, and this point is clearly exemplified in…
Prognostic Value of HMGA2 in Human Cancers: A Meta-Analysis Based on Literatures and TCGA Datasets
Abstract Background: Emerging evidences have shown that the high-mobility group protein A2 (HMGA2) can aberrantly express in human cancers, and…
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
Abstract UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone…