Identification of hub genes and potential molecular mechanisms related to radiotherapy in thyroid cancer
Abstract Radiotherapy is a common approach during the treatment of thyroid cancer (THCA). It is urgent to identify the radiotherapy-related…
De-Jie Zhang
Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2′-O-Methyltransferase (2′-O-MTase) Non-Structural Protein (Nsp10–16)
Abstract The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps)…
Systematic review/meta‐analysis on the role of CB1R regulation in sleep‐wake cycle in rats
Abstract Objective: A systematic review/meta‐analysis was conducted to investigate the effect of cannabinoid type‐1 receptor (CB1R) regulation on the sleep‐wake…
Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
Abstract Background: Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether…
Resilience, organizational support, and innovative behavior on nurses’ work engagement: a moderated mediation analysis
Abstract Objectives: To investigate the status of nurses’ work engagement and the relationship among resilience, organizational support, and innovative behaviors.…
Pan-cancer analysis of the prognostic and immunological role of matrix metalloproteinase 9
Abstract Matrix metalloproteinase 9 (MMP9), a zinc ion-dependent endopeptidase, is one of the most complex matrix metalloproteinases in the gelatinase…
Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer
Abstract Background: Numerous studies have shown that the insulin‐like growth factor (IGF) pathway is highly associated with tumor initial and…
Comprehensive identification and expression analyses of the SnRK gene family in Casuarina equisetifolia in response to salt stress
Abstract Background: Sucrose nonfermenting-1 (SNF1)-related protein kinases (SnRKs) play crucial roles in plant signaling pathways and stress adaptive responses by…
Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation
Abstract Objective: Contextual drug-associated memory precipitates craving and relapse in substance users, and the risk of relapse is a major…
The role of toll-like receptors (TLRs) in pan-cancer
Abstract Background: Toll-like receptors (TLRs) are important components of the innate and adaptive immune systems, and abnormal TLR expression has…