David Andreu

December 27, 2024

Design of Small Non-Peptidic Ligands That Alter Heteromerization between Cannabinoid CB1 and Serotonin 5HT2A Receptors

Abstract Activation of cannabinoid CB1 receptors (CB1R) by agonists induces analgesia but also induces cognitive impairment through the heteromer formed…

January 11, 2022

Disrupting GPCR Complexes with Smart Drug-like Peptides

Abstract G protein-coupled receptors (GPCRs) are a superfamily of proteins classically described as monomeric transmembrane (TM) receptors. However, increasing evidence…

April 23, 2021

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

Abstract The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R…