Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer
Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack…
Danjie Pan
Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy
Abstract Collagen, the most abundant protein in mammal, is widely expressed in tissues and organs, as well as tumor extracellular…
A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer
Abstract The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor…