Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
Abstract We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands with a tailored functional…
Chuntian Huang
Structural basis of selective cannabinoid CB2 receptor activation
Abstract Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action is not…
MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1
Abstract Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor (GPCR) that is gaining much interest for its regulating role…
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
Abstract Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes…