CDCM: a correlation-dependent connectivity map approach to rapidly screen drugs during outbreaks of infectious diseases
Abstract In the context of the global damage caused by coronavirus disease 2019 (COVID-19) and the emergence of the monkeypox…
Chun-Hao Wang
Pan‐Cancer Single‐Cell Transcriptomic Analysis Reveals Divergent Expression of Embryonic Proangiogenesis Gene Modules in Tumorigenesis
Abstract Background: Angiogenesis is indispensable for the sustained survival and progression of both embryonic development and tumorigenesis. This intricate process…
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of…
Identification and Validation of a Prognostic Signature Based on Methylation Profiles and Methylation-Driven Gene DAB2 as a Prognostic Biomarker in Differentiated Thyroid Carcinoma
Abstract Recurrence is the major death cause of differentiated thyroid carcinoma (DTC), and a better understanding of recurrence risk at…
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer
Abstract Background: Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for patients with CRC are…
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker
Abstract Background: Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator associated arginine methyltransferase 1 (CARM1)…