Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-31042-w. Article type: Research Article Keywords: Pan-cancer, E2F family,…
Abstract Background: Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein function and hinder DNA repair, leading to…
Abstract Colorectal cancer (CRC) exhibits significant heterogeneity, impacting immunotherapy efficacy, particularly in immune desert subtypes. Neuromedin U receptor 1 (NMUR1)…
Abstract Background: In the realm of tumor-targeted therapeutics, Polo-like kinases (PLKs) are a significant group of protein kinases that were…