Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer
Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack…
Chengjin Zhang
The pharmacology and therapeutic role of cannabidiol in diabetes
Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad…
Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers.
Abstract Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1) and…
An integrated multi-omics analysis of topoisomerase family in pan-cancer: Friend or foe?
Abstract Background: Topoisomerases are nuclear enzymes that get to the bottom of topological troubles related with DNA all through a…
Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways
Abstract Three unique 5,6-seco-hexahydrodibenzopyrans (seco-HHDBP) machaeridiols A–C, reported previously from Machaerium Pers., have displayed potent activities against methicillin-resistant Staphylococcus aureus…
A high-quality reference genome of wild Cannabis sativa
Abstract Cannabis sativa is a well-known plant species that has great economic and ecological significance. An incomplete genome of cloned…
Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction
Abstract We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms…
Identification of cancer-related miRNA-lncRNA biomarkers using a basic miRNA-lncRNA network
Abstract LncRNAs are regulatory noncoding RNAs that play crucial roles in many biological processes. The dysregulation of lncRNA is thought…