RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
Abstract Activating mutations in KRAS occur in 32% of lung adenocarcinomas (LUAD). Despite leading to aggressive disease and resistance to…
Charles Swanton
Computational optimisation of targeted DNA sequencing for cancer detection
Abstract Despite recent progress thanks to next-generation sequencing technologies, personalised cancer medicine is still hampered by intra-tumour heterogeneity and drug…