Data-driven universal insights into tumorigenesis via hallmark networks
Abstract Cancers are complex diseases characterized by dynamic perturbations of regulatory networks across multiple hierarchical levels, which cannot be fully…
Chaoyang Li
Profiling bile acid composition in bile from mice of different ages and sexes
Abstract Introduction: Bile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile…
The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation
Abstract Since the seminal report by Adachi and co-workers in 2012, there has been a veritable explosion of interest in…
A Pan-Cancer Analysis of the Oncogenic Role of CD276 in Human Tumors
Abstract Objectives: B7 homolog 3 protein (B7-H3, also known as CD276) is a member of the B7 family that has…
Cannabidiol inhibits transient receptor potential canonical 4 and modulates excitability of pyramidal neurons in mPFC
Abstract Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been extensively studied for its potential therapeutic effects…
NEK2 is a potential pan-cancer biomarker and immunotherapy target
Abstract Background: NEK2 is a member of the NEKs family and plays an important role in cell mitosis. Increasing evidence…
How to improve public environmental health by facilitating metro usage on weekend: exploring the non-linear and threshold impacts of the built environment
Abstract Introduction: The accelerated motorization has brought a series of environmental concerns and damaged public environmental health by causing severe…
Structural insights into human ABCD3-mediated peroxisomal acyl-CoA translocation
Abstract Human ABC transporters ABCD1–3 are all localized on the peroxisomal membrane and participate in the β-oxidation of fatty acyl-CoAs,…
Novel T cell exhaustion gene signature to predict prognosis and immunotherapy response in thyroid carcinoma from integrated RNA-sequencing analysis
Abstract Exhausted CD8+ T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis and the efficacy of immunotherapy.…
A paradigm shift in cancer research based on integrative multi-omics approaches: glutaminase serves as a pioneering cuproptosis-related gene in pan-cancer
Abstract Background: Cuproptosis is a newly identified form of unprogrammed cell death. As a pivotal metabolic regulator, glutaminase (GLS) has…