Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and limited treatment options. While the majority…
Abstract It has been well established that cancer cells can evade immune surveillance by mutating themselves. Understanding genetic alterations in…
Abstract Although immunotherapy has made great strides in cancer therapy, its effectiveness varies widely among individual patients as well as…
Abstract Background: Disorders of CD274 and PDCD1LG2 contribute to immune escape in human cancers, and treatment with anti-programmed death receptor…
Abstract LYAR (Ly-1 antibody reactive) is a transcription factor with a specific DNA-binding domain, which plays a key role in…
Abstract The high mobility group box (HMGB) protein family consists of four members: HMGB1, 2, 3, and 4. They share…