Abstract Background: The mental health benefits of cannabidiol (CBD) are promising but can be inconsistent, in part due to challenges…
Abstract Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially…
Abstract Introduction: The primary compounds of Cannabis sativa, delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), inflict a direct influence on the endocannabinoid…
Abstract Adolescent individuals often present with subtle, sub-threshold psychiatric syndromes that fluctuate or persist for years. These symptoms have been…
Abstract Cannabidiol (CBD), a principal phytocannabinoid constituent, has demonstrated antipsychotic properties in recent clinical trials. While it has also been…
Abstract The two main phytocannabinoids—delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)—have been extensively studied, and it has been shown that THC can…
Abstract There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system…