Best holdout assessment is sufficient for cancer transcriptomic model selection
Abstract Guidelines in statistical modeling for genomics hold that simpler models have advantages over more complex ones. Potential advantages include…
Casey S. Greene
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Abstract DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide…
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
Abstract Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may…