Abstract Background: T-cell receptor (TCR) repertoires provide insights into tumor immunology, yet their variations across digestive system cancers are not…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-86185-7. Article type: Research Article Keywords: FLT3, AML, Hepatocellular…
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and limited treatment options. While the majority…
Abstract Background: Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly influences drug responses, with…
Abstract Background: Before the discovery of cuproptosis, copper-loaded nanoparticle is a wildly applied strategy for enhancing the tumor-cell-killing effect of…
Abstract Large amounts of potash fertilizer are often applied to apple (Malus domestica) orchards to enhance fruit quality and yields,…
Abstract Background: Immunogenic cell death (ICD) is a result of immune cell infiltration (ICI)-mediated cell death, which is also a…
Abstract Although immunotherapy has made great strides in cancer therapy, its effectiveness varies widely among individual patients as well as…
Abstract Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions and is pursued as an…
Abstract Numerous studies have demonstrated that lncRNAs could compete with other RNAs to bind miRNAs, as competing endogenous RNAs (ceRNAs),…