Abstract Formation of transcription factor (TF)–coregulator complexes is a key step in transcriptional regulation, with coregulators having essential functions as…
Abstract Intrinsically disordered proteins (IDPs) regularly constitute components of larger protein assemblies contributing to architectural stability. Two small, highly acidic…
Abstract Integrative structure of a complete cytokine receptor in a nanodisc opens for mechanistic decoding of disorder-based biology. Authors: Noah…
Abstract Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known…
Abstract Dynamic interactions of proteins with lipid membranes are essential regulatory events in biology, but remain rudimentarily understood and particularly…
Abstract Background: Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the…
Abstract The prolactin receptor is an archetype member of the class I cytokine receptor family, comprising receptors with fundamental functions…