A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation
Abstract Background: Human immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with…
Benjamin F. Cravatt
GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration
Abstract Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role…
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Abstract Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in…