The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Benjamin Bourgeois
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Abstract Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share…
EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner
Abstract Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported.…
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR…