The impact of rare germline variants on human somatic mutation processes
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types…
Ben Lehner
Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
Abstract The genetic causes of cancer include both somatic mutations and inherited germline variants. Large-scale tumor sequencing has revolutionized the…
MUFFINN: cancer gene discovery via network analysis of somatic mutation data
Abstract Electronic supplementary material: The online version of this article (doi:10.1186/s13059-016-0989-x) contains supplementary material, which is available to authorized users.…