Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse
Abstract Introduction: Cannabis holds therapeutic potential; however, activation of the type 1 cannabinoid receptor (CB1R) via Δ9-tetrahydrocannabinol (THC) is also…
Ayat Zagzoog
Characterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure
Abstract Cannabis sativa has gained popularity as a “natural substance”, leading many to falsely assume that it is not harmful.…
Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593
Abstract Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune…
Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
Abstract Cannabis sativa contains more than 120 cannabinoids and 400 terpene compounds (i.e., phytomolecules) present in varying amounts. Cannabis is…
Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes
Abstract Sexual dimorphisms are observed in cannabinoid pharmacology. It is widely reported that female animals are more sensitive to the…
In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors
Abstract The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep,…
Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor
Abstract The first synthetic cannabinoid receptor agonists (SCRAs) were designed as tool compounds to study the endocannabinoid system’s two predominant…
In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
Abstract The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), comparatively…
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling
Abstract In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin…