Abstract Cannabis sativa has gained popularity as a “natural substance”, leading many to falsely assume that it is not harmful.…
Abstract Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune…
Abstract Cannabis sativa contains more than 120 cannabinoids and 400 terpene compounds (i.e., phytomolecules) present in varying amounts. Cannabis is…
Abstract Sexual dimorphisms are observed in cannabinoid pharmacology. It is widely reported that female animals are more sensitive to the…
Abstract The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep,…
Abstract The first synthetic cannabinoid receptor agonists (SCRAs) were designed as tool compounds to study the endocannabinoid system’s two predominant…
Abstract The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), comparatively…
Abstract In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin…