A pan-cancer survey of cell line tumor similarity by feature-weighted molecular profiles
Abstract Patient-derived cell lines are often used in pre-clinical cancer research, but some cell lines are too different from tumors…
Augustin Luna
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Abstract Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles…
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
Abstract Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may…