Cannabidiol induces autophagy via ERK1/2 activation in neural cells
Abstract Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central…
Antonio W. Zuardi
Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study
Abstract Objective: To assess the efficacy of cannabidiol (CBD) in the management of crack-cocaine craving and the treatment of frequent…
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Abstract Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can…
Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
Abstract Objective: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped…
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
Abstract Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the…
Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia
Abstract Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its pharmacotherapy remains problematic without recent major advances. The development…
No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Abstract Cannabidiol (CBD) is a component of Cannabis sativa that has a broad spectrum of potential therapeutic effects in neuropsychiatric…
Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
Abstract Background: Pain involves different brain regions and is critically determined by emotional processing. Among other areas, the rostral anterior…
Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
Abstract The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD) in humans follows the…
Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy
Abstract The present study reports the behavioral, electrophysiological, and neuropathological effects of cannabidiol (CBD), a major non-psychotropic constituent of Cannabis…