An improved epigenetic counter to track mitotic age in normal and precancerous tissues
Abstract The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a…
Andrew E. Teschendorff
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains
Abstract Cancer is characterized by both genetic and epigenetic alterations. While cancer driver mutations and copy-number alterations have been studied…
An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
Abstract Background: One of the most important recent findings in cancer genomics is the identification of novel driver mutations which…
Corruption of the Intra-Gene DNA Methylation Architecture Is a Hallmark of Cancer
Abstract Epigenetic processes – including DNA methylation – are increasingly seen as having a fundamental role in chronic diseases like…