Abstract The endocannabinoid N‐arachidonoylethanolamine (AEA) is a pro‐homeostatic bioactive lipid known for its anti‐inflammatory, anti‐oxidative, immunomodulatory, and neuroprotective properties, which…
Abstract Brain aging is associated with cognitive decline, reduced synaptic plasticity, and altered metabolism. The activity of mechanistic target of…
Abstract Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine…
Abstract Endocannabinoid (eCB) signaling is markedly decreased in the hippocampus (Hip) of aged mice, and the genetic deletion of the…
Abstract The endocannabinoid system consists mainly of 2-arachidonoylglycerol and anandamide, as well as cannabinoid receptor type 1 and type 2…
Abstract Physiological brain aging is characterized by gradual, substantial changes in cognitive ability, accompanied by chronic activation of the neural…
Abstract Decline in cognitive performance, an aspect of the normal aging process, is influenced by the endocannabinoid system (ECS). Cannabinoid…
Abstract Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role…
Abstract Microglia, the resident immune cells of the brain, play important roles in defending the brain against pathogens and supporting…
Abstract Objective: The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI)…