CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice☆
Abstract Recreational use of synthetic cannabinoid agonists (i.e., “spice compounds”) that target the cannabinoid type 1 receptor (CB1) can cause…
Andrea G. Hohmann
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is…
Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice
Abstract Background: The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress…
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain
Abstract Supplemental Digital Content is Available in the Text. Article type: Research Article Keywords: Cannabinoids, Cannabis-based medicine, Endocannabinoid system modulator,…
Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward
Abstract Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However,…