Andrea Chicca

March 26, 2021

Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis

Abstract The modulation of the endocannabinoid system (ECS) has shown positive results in animal models of multiple sclerosis (MS) and…

January 3, 2017

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Abstract The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases.…

May 13, 2015

4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

Abstract Background and purpose: 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to…