Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer
Abstract Sodium iodide symporter (NIS) expression in breast cancer renders radioiodide (RAI) a promising treatment modality. However, insufficient functional NIS…
Alice Fletcher
Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo
Abstract Purpose: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due…
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter
Abstract The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells.…
Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors
Abstract Context: Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical…