Forty sites of TRP channel regulation
Abstract Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert…
Alexander I. Sobolevsky
TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Abstract TRPV3 represents both temperature- and ligand-activated transient receptor potential (TRP) channel. Physiologically relevant opening of TRPV3 channels by heat…
Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
Abstract Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this…
Molecular pharmacology of the onco-TRP channel TRPV6
Abstract TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the…
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
Abstract The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological…
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Abstract Significance Statement: Glutamate receptors play important roles in virtually all aspects of brain function and are either involved in…