Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis
Abstract Cogent evidence shows that cannabis plays a variable role on behavioral regulation and the pathophysiology of most psychiatric conditions.…
Review Article
Dendritic Cell Regulation by Cannabinoid-Based Drugs
Abstract Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models…
Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
Abstract The endocannabinoid system has been shown to be associated with neurodegenerative diseases and dementia. We review the preclinical and…
The Role of Cannabinoid Receptors in the Descending Modulation of Pain
Abstract The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract…
The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism
Abstract Phytocannabinoids present in Cannabis plants are well known to exert potent anti-inflammatory and immunomodulatory effects. Previously, we have demonstrated…
Cannabinoids for the Treatment of Schizophrenia? A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use
Abstract Recent studies have found that cannabinoids may improve neuropsychological performance, ameliorate negative symptoms, and have antipsychotic properties for a…
Treatment of Irritability in Huntington’s Disease
Abstract Irritability is a common neuropsychiatric feature of Huntington’s disease (HD), with prevalences varying from 38% to 73%. Similar prevalences…
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
Abstract Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol. It is well-known…
Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms
Abstract Cannabinoids are used clinically on a subacute basis as prophylactic agonist antiemetics for the prevention of nausea and vomiting…
Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents
Abstract Rationale: Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial…