A potential role for GPR55 in gastrointestinal functions
Abstract ► GPR55 is a putative cannabinoid receptor. ► GPR55 shares little homology (10–15%) with cannabinoid-1 (CB1) and cannabinoid-2 (CB2)…
Review Article
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
Abstract Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome,…
A mechanism-based classification of pain in multiple sclerosis
Abstract Pharmacological treatment of pain in multiple sclerosis (MS) is challenging due to the many underlying pathophysiological mechanisms. Few controlled…
Association of Marijuana Use and Cyclic Vomiting Syndrome
Abstract Cannabis use has become one of the most commonly abused drugs in the world. It is estimated that each…
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Abstract There is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in…
Association of Cannabis Use during Adolescence, Prefrontal CB1 Receptor Signaling, and Schizophrenia
Abstract The cannabinoid receptor 1 (CB1R) is the G-protein coupled receptor responsible for the majority of the endocannabinoid signaling in…
Neuroimaging Evidence for Cannabinoid Modulation of Cognition and Affect in Man
Authors: Sagnik Bhattacharyya, Kyra-Verena Sendt Affiliations: Department of Psychosis Studies, Institute of Psychiatry, King’s College LondonLondon, UK License: Copyright ©…
Cannabidiol in Humans—The Quest for Therapeutic Targets
Abstract Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, is attracting growing attention in medicine for its anxiolytic, antipsychotic, antiemetic…
Endocannabinoid–Dopamine Interactions in Striatal Synaptic Plasticity
Abstract The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on…
Update on the Role of Cannabinoid Receptors after Ischemic Stroke
Abstract Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been…