Safety and Toxicology of Cannabinoids
Abstract Electronic supplementary material: The online version of this article (doi:10.1007/s13311-015-0380-8) contains supplementary material, which is available to authorized users.…
Review Article
Review of available studies of the neurobiology and pharmacotherapeutic management of trichotillomania
Keywords: Trichotillomania (TTM), Neurobiology, Rating scales, Clinical trials Authors: Jacklyn Johnson, Abir T. El-Alfy License: © 2015 Production and hosting…
The Importance of Biological Oscillators for Hypothalamic-Pituitary-Adrenal Activity and Tissue Glucocorticoid Response: Coordinating Stress and Neurobehavioural Adaptation
Abstract The hypothalamic-pituitary-adrenal (HPA) axis is critical for life. It has a circadian rhythm that anticipates the metabolic, immunoregulatory and…
Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
Abstract Drug addiction is a chronically relapsing disorder characterized by the compulsive desire to use drugs and a loss of…
Sex-Dependent Vulnerability to Cannabis Abuse in Adolescence
Abstract The goal of this review is to summarize current evidence for sex differences in the response to cannabinoid compounds,…
The therapeutic potential of orphan GPCRs, GPR35 and GPR55
Abstract The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family of signal transducers, comprised of ∼1000…
Role of the Endogenous Cannabinoid System in Nicotine Addiction: Novel Insights
Abstract Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and…
Management of Neuropathic Pain Associated with Spinal Cord Injury
Abstract Spinal cord injury (SCI) is an injury to the spinal cord that leads to varying degrees of motor and/or…
Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Abstract The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins,…
Endocannabinoids and striatal function: implications for addiction-related behaviours
Abstract Since the identification and cloning of the major cannabinoid receptor expressed in the brain almost 25 years ago research…