Ajulemic acid: potential treatment for chronic inflammation
Abstract Ajulemic acid (AJA, CT‐3, IP‐751, JBT‐101, anabasum) is a first‐in‐class, synthetic, orally active, cannabinoid‐derived drug that preferentially binds to…
Review Article
Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies
Abstract Background and Objectives: Opioid use disorder (OUD) is a chronic condition with potentially severe health and social consequences. Many…
Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders
Abstract A substantial body of credible evidence has accumulated that suggest that cannabis use is an important potentially preventable risk…
A Pharmacological Rationale to Reduce the Incidence of Opioid Induced Tolerance and Hyperalgesia: A Review
Abstract Chronic pain is an important health and social problem. Misuse and abuse of opioids in chronic non-cancer pain management…
The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders
Abstract Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The…
Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review
Abstract Mycobacterium marinum is an opportunistic pathogen inducing infection in fresh and marine water fish. This pathogen causes necrotizing granuloma…
Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down—and meeting in the middle
Abstract Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active…
Cannabis Addiction and the Brain: a Review
Abstract Cannabis is the most commonly used substance of abuse in the United States after alcohol and tobacco. With a…
Megestrol acetate for cachexia–anorexia syndrome. A systematic review
Abstract In 1993, megestrol acetate (MA) was approved by the US Food and Drug Administration for the treatment of anorexia,…
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
Abstract The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by…