Targeted genome editing in acute lymphoblastic leukemia: a review
Abstract Background: Genome editing technologies offers new opportunities for tackling diseases such as acute lymphoblastic leukemia (ALL) that have been…
Review Article
Cannabinoids, the Heart of the Matter
Keywords: calcium channel, cannabinoids, cell signaling, drug abuse, drug therapy, heart disease, marijuana, transmembrane spanning receptors, Lifestyle, Cardiovascular Disease, Heart…
Effects of Adolescent THC Exposure on the Prefrontal GABAergic System: Implications for Schizophrenia-Related Psychopathology
Abstract Marijuana is the most commonly used drug of abuse among adolescents. Considerable clinical evidence supports the hypothesis that adolescent…
Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
Abstract Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current…
GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling
Abstract G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling receptors implicated in various types of…
Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases
Abstract Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the well-known psychotropic activity. C. Sativa is…
Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy
Abstract Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well-known side…
Marijuana Use Among Adults 50 Years or Older in the 21st Century
Abstract Background: Marijuana is the most commonly used illicit drug among older adults. As an older population grows in the…
Cannabinoid ligands, receptors and enzymes: Pharmacological tools and therapeutic potential
Abstract Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of…
Addictive potential of novel treatments for refractory depression and anxiety
Abstract Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or…