Cannabinoid Regulation of Fear and Anxiety: an Update
Abstract Purpose of Review: Anxiety- and trauma-related disorders are prevalent and debilitating mental illnesses associated with a significant socioeconomic burden.…
Review Article
Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield
Abstract Until recently, the commercial production of Cannabis sativa was restricted to varieties that yielded high-quality fiber while producing low…
Intracellular Peptides in Cell Biology and Pharmacology
Abstract Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed…
Structural Insights into CB1 Receptor Biased Signaling
Abstract The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders,…
Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
Abstract Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and…
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Abstract With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden…
The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
Abstract The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last decade. The immense data load…
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Abstract Healthcare is undergoing a transformation, and it is imperative to leverage new technologies to generate new data and support…
Future Aspects for Cannabinoids in Breast Cancer Therapy
Abstract Cannabinoids (CBs) from Cannabis sativa provide relief for tumor-associated symptoms (including nausea, anorexia, and neuropathic pain) in the palliative…
Core Outcome Measures in Preclinical Assessment of Candidate Analgesics
Abstract All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain stimulus” (the principal independent variable), which…