Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
Abstract Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes…
Review Article
Prenatal Cannabinoid Exposure: Emerging Evidence of Physiological and Neuropsychiatric Abnormalities
Abstract Clinical reports of cannabis use prevalence during pregnancy vary widely from 3% to upwards of 35% in North America;…
Cannabinoids and orthopedic surgery: a systematic review of therapeutic studies
Abstract Background: Recent work has shed light on the potential benefits of cannabinoids for multimodal pain control following orthopedic procedures.…
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Abstract Autism spectrum disorder (ASD) is comprised of several conditions characterized by alterations in social interaction, communication, and repetitive behaviors.…
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
Abstract Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity.…
Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives
Abstract Recent pharmacoepidemiologic studies suggest that pharmacological neuroenhancement (pNE) and mood enhancement are globally expanding phenomena with distinctly different regional…
Do Adolescent Exposure to Cannabinoids and Early Adverse Experience Interact to Increase the Risk of Psychiatric Disorders: Evidence from Rodent Models
Abstract There have been growing concerns about the protracted effects of cannabis use in adolescents on emotion and cognition outcomes,…
Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases
Abstract Autoimmune diseases, including psoriasis, systemic lupus erythematosus (SLE), and rheumatic arthritis (RA), are caused by a combination of environmental…
Cannabidiol for the Treatment of Neonatal Hypoxic-Ischemic Brain Injury
Abstract Each year, more than two million babies die or evolve to permanent invalidating sequelae worldwide because of Hypoxic-Ischemic Brain…
Peroxisomal Metabolite and Cofactor Transport in Humans
Abstract Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number…