Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease
Abstract Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to recurrent and…
Review Article
Natural Salicylates and Their Roles in Human Health
Abstract Salicylic acid (SA) is a plant hormone which plays a crucial role in the plant defense against various pathogens…
The Immune Endocannabinoid System of the Tumor Microenvironment
Abstract Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory…
Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective
Abstract Cannabis has been used for centuries for recreational and therapeutic purposes. Whereas, the recreative uses are based on the…
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action
Abstract Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and…
Cannabis in Gastroenterology: Watch Your Head! A Review of Use in Inflammatory Bowel Disease, Functional Gut Disorders, and Gut-Related Adverse Effects
Abstract Purpose of review: To review recent clinical evidence surrounding the use of cannabinoids and cannabis in gastrointestinal diseases, particularly…
Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders
Abstract The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric…
Can We Treat Neuroinflammation in Alzheimer’s Disease?
Abstract Alzheimer’s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial,…
A Systematic Review of Interventions to Improve Mental Health and Substance Use Outcomes for Individuals with Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder
Abstract Individuals with fetal alcohol spectrum disorder (FASD) experience remarkably high rates of mental health and substance use challenges, beginning…
The Endocannabinoid System Activation as a Neural Network Desynchronizing Mediator for Seizure Suppression
Abstract The understanding that hyper-excitability and hyper-synchronism in epilepsy are indissociably bound by a cause-consequence relation has only recently been…