Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy
Abstract Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating, storage, and transport mechanisms are required to maintain…
Review Article
Medical Cannabis, Headaches, and Migraines: A Review of the Current Literature
Abstract Cannabis has been long used since ancient times for both medical and recreational use. Past research has shown that…
Cannabidiol modulation of oxidative stress and signalling
Abstract Cannabidiol (CBD), one of the primary non-euphoric components in the Cannabis sativa L. plant, has undergone clinical development over…
Review: Prevalence of Addictions among Transgender and Gender Diverse Subgroups
Abstract We conducted an analysis of the prevalence of substance and behavioral addictions across different transgender and gender diverse (TGD)…
GABAA receptors: structure, function, pharmacology, and related disorders
Abstract Background: γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?
Abstract Fibromyalgia syndrome (FMS) is a pain disorder characterized by chronic widespread pain, fatigue, and sleep disturbance, in the absence…
The CB2 Receptor as a Novel Therapeutic Target for Epilepsy Treatment
Abstract Epilepsy is characterized by repeated spontaneous bursts of neuronal hyperactivity and high synchronization in the central nervous system. It…
Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα
Abstract In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability to degrade fatty acid chains. Although each…
Cannabis, Impaired Driving, and Road Safety: An Overview of Key Questions and Issues
Abstract The road safety impact of cannabis has been a topic of much discussion and debate over the years. These…