15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been…
Review Article
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
Abstract Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge…
Gene-Environment Interactions in Schizophrenia: A Literature Review
Abstract Schizophrenia is a devastating mental illness with a strong genetic component that is the subject of extensive research. Despite…
Probing Isoform Switching Events in Various Cancer Types: Lessons From Pan-Cancer Studies
Abstract Alternative splicing is an essential regulatory mechanism for gene expression in mammalian cells contributing to protein, cellular, and species…
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s40263-021-00879-w. Authors: Frank Petzke ⚬, Thomas Tölle ⚬, Mary-Ann…
Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
Abstract The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor…
The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies
Abstract Simple Summary: Cannabinoids have been shown to suppress tumour cell proliferation, tumour invasion, metastasis, angiogenesis, chemoresistance and epithelial-mesenchymal transition…
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
Abstract Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in…
The Vertical and Horizontal Pathways in the Monkey Retina Are Modulated by Typical and Atypical Cannabinoid Receptors
Abstract The endocannabinoid (eCB) system has been found in all visual parts of the central ner-vous system and plays a…
Cannabinoid Drugs-Related Neuroprotection as a Potential Therapeutic Tool Against Chemotherapy-Induced Cognitive Impairment
Abstract In recent years, and particularly associated with the increase of cancer patients’ life expectancy, the occurrence of cancer treatment…