Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review
Abstract Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug discovery is a paramount need. Cannabis…
Review Article
The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies
Abstract Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need…
15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been…
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
Abstract Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge…
Gene-Environment Interactions in Schizophrenia: A Literature Review
Abstract Schizophrenia is a devastating mental illness with a strong genetic component that is the subject of extensive research. Despite…
Probing Isoform Switching Events in Various Cancer Types: Lessons From Pan-Cancer Studies
Abstract Alternative splicing is an essential regulatory mechanism for gene expression in mammalian cells contributing to protein, cellular, and species…
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s40263-021-00879-w. Authors: Frank Petzke ⚬, Thomas Tölle ⚬, Mary-Ann…
Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
Abstract The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor…
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
Abstract Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in…
The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies
Abstract Simple Summary: Cannabinoids have been shown to suppress tumour cell proliferation, tumour invasion, metastasis, angiogenesis, chemoresistance and epithelial-mesenchymal transition…