Targeting the Endocannabinoidome in Pancreatic Cancer
Abstract Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer…
Review Article
Study Design Characteristics and Endpoints for Enriched Enrollment Randomized Withdrawal Trials for Chronic Pain Patients: A Systematic Review
Abstract Enriched enrollment randomized withdrawal (EERW) pain trials are designed to include only responders with considerable pain relief without unacceptable…
Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review
Abstract Purposes: In addition to its role in cellular progression and cancer, SIRT6, a member of nicotinamide adenine dinucleotide (NAD+)-dependent…
The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors
Abstract The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased…
Cannabidiol (CBD) in Cancer Management
Abstract Simple Summary: Cannabidiol (CBD) is one of the main constituents of the plant Cannabis sativa. Surveys suggest that medicinal…
“The Two Sides of the Same Coin”—Medical Cannabis, Cannabinoids and Immunity: Pros and Cons Explained
Abstract Cannabis, as a natural medicinal remedy, has long been used for palliative treatment to alleviate the side effects caused…
Patterns of Cannabis and Alcohol Co-Use: Substitution Versus Complementary Effects
Abstract PURPOSE: The purpose of this review is to discuss the literature regarding the concurrent use (co-use) of alcohol and…
Fragile X Syndrome: From Molecular Aspect to Clinical Treatment
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the full mutation as well as highly localized methylation…
Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review
Abstract The use of natural products in dermatology is increasingly being pursued due to sustainability and ecological issues, and as…
Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder
Abstract Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with only three widely-approved pharmacotherapies. Given that…