Therapeutic potential of acidic cannabinoids: an update
Abstract Cannabis sativa yields a wide range of bioactive compounds, including terpenes, flavonoids, and cannabinoids. Tetrahydrocannabinolic acid (THCA), cannabidiolic acid…
Review Article
Chronic Pain in Multiple Sclerosis: Mechanisms, Clinical Characteristics and Treatment Strategies
Abstract Chronic pain is an underestimated and undertreated yet highly prevalent symptom in people with multiple sclerosis (pwMS), significantly impairing…
Cannabidiol–Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma
Abstract Hepatocellular carcinoma (HCC) is the main type of liver cancer and one of the malignancies with the highest mortality…
Cancer cachexia: molecular basis and therapeutic advances
Abstract The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis…
The role of the endocannabinoid system in managing neuropsychiatric symptoms in Alzheimer’s disease
Abstract The endocannabinoid system comprises cannabinoid receptors (CBRs) 1 & 2, endocannabinoids (eCBs) anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and the…
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of toxic protein aggregates in the brain, leading…
Toxicity and health effects of delta-8, delta-9, and delta-10-tetrahydrocannabinol and unregulated cannabinoids in vaping products
Abstract Hemp-derived cannabinoids (CBDs) such as Δ8- and Δ10-tetrahydrocannabinol (THC) in cannabis e-cigarettes have been growing in popularity among youth,…
Recent Developments in Protein-Based Hydrogels for Advanced Drug Delivery Applications
Abstract Protein-based hydrogels are increasingly recognized as promising biomaterials for advanced drug delivery, owing to their biocompatibility, biodegradability, and ability…
Cannabis Use in Orthopaedic Surgery: Effects on Fracture Healing, Opioid Requirements, and Clinical Outcomes
Abstract Cannabis is commonly used by patients presenting for orthopaedic care, including musculoskeletal pain, sleep disturbances, anxiety, or recreational purposes.…
Light-Controlled Modulation of the Endocannabinoid System: Photoswitchable Ligands for Cannabinoid and TRPV1 Receptors
Abstract Photopharmacology is an emerging field in medicinal chemistry that seeks to control the pharmacological effects of target compounds using…