Biomarkers of the Endocannabinoid System in Substance Use Disorders
Abstract Despite substance use disorders (SUD) being one of the leading causes of disability and mortality globally, available therapeutic approaches…
Review Article
Emerging Antifungal Targets and Strategies
Abstract Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is…
Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part I-Development
Abstract The process of method development for a diagnostic assay based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) involves several disparate…
Novel Psychoactive Substances: The Razor’s Edge between Therapeutical Potential and Psychoactive Recreational Misuse
Abstract Background: Novel psychoactive substances (NPS) are compounds of natural and synthetic origin, similar to traditional drugs of abuse. NPS…
Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review
Abstract Cannabis sativa L. is an annual herb oldest cultivated plants as a source of fiber since about 5000 B.C.…
Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression
Abstract Receptors are macromolecules that transmit information regulating cell proliferation, differentiation, migration and apoptosis, play key roles in oncogenic processes…
Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review
Abstract Introduction: Patients with head and neck cancer (HNC) are usually confronted with functional changes due to the malignancy itself…
The Construct of Medical and Non-Medical Marijuana—Critical Review
Abstract The rising popularity of medical marijuana and its potential therapeutic uses has resulted in passionate discussions that have mainly…
Development of a dynamic network biomarkers method and its application for detecting the tipping point of prior disease development
Abstract The dynamic network biomarker (DNB) method has advanced since it was first proposed. This review discusses advances in the…
Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination
Abstract Despite current therapeutic strategies for immunomodulation and relief of symptoms in multiple sclerosis (MS), remyelination falls short due to…