A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management
Abstract Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial number of patients facing drug-resistant epilepsy. This…
Review Article
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Abstract Background: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifelong seizures. The management of…
Socioeconomic and psychosocial determinants of substance misuse – a national perspective
Abstract Accurate estimates of population drug use and an understanding of the factors that influence substance choice are essential for…
Cannabis and Other Substance Misuse: Implications and Regulations
Abstract Abusing controlled substances, including cannabis and various drugs, can result in severe intoxication and even death. Therefore, a comprehensive…
Looking Back, Moving Forward in Pain Medicine
Abstract Pain is an ancient medical complaint and a clinical riddle that has never been entirely solved. Looking back into…
Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomics
Abstract Much recent attention has been directed toward the spatial organization of the cell nucleus and the manner in which…
Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs
Abstract Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam and in late 2021 arose on the…
The role of microorganisms in the biotransformation of psychoactive substances and its forensic relevance: a critical interdisciplinary review
Abstract : Microorganisms are widespread on the planet being able to adapt, persist, and grow in diverse environments, either rich…
Obstructive sleep apnea phenotypes eligible for pharmacological treatment
Abstract Obstructive sleep apnea (OSA) is a common disorder. Its prevalence is increasing worldwide, partially due to increasing rates of…
Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review
Abstract Background: Compelling evidence from preclinical and clinical studies supports the therapeutic role of cannabidiol (CBD) in several medical disorders.…