Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors
Abstract The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other…
Research Article
Spatio-Temporal and Cultivar-Dependent Variations in the Cannabis Microbiome
Abstract The incipient legalization and commercialization of Cannabis sativa in Canada have promulgated research into characterizing the plant’s microbiome as…
Interaction of Cannabis Use Disorder and Striatal Connectivity in Antipsychotic Treatment Response
Abstract Antipsychotic (AP) medications are the mainstay for the treatment of schizophrenia spectrum disorders (SSD), but their efficacy is unpredictable…
Time- and temperature-dependent postmortem concentration changes of the (synthetic) cannabinoids JWH-210, RCS-4, as well as ∆9-tetrahydrocannabinol following pulmonary administration to pigs
Abstract In forensic toxicology, interpretation of postmortem (PM) drug concentrations might be complicated due to the lack of data concerning…
Influence of Altitude on Phytochemical Composition of Hemp Inflorescence: A Metabolomic Approach
Abstract The phytochemical profiling of hemp inflorescences of clonal plants growing in different conditions related to altitude was investigated. Four…
Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets
Abstract Background: The oil from industrial hemp seeds (Cannabis sativa) is an ideal source of stearidonic acid, which is a…
Urban wastewater analysis as an effective tool for monitoring illegal drugs, including new psychoactive substances, in the Eastern European region
Abstract The use of illicit drugs causes unquestionable societal and economic damage. To implement actions aimed at combating drug abuse,…
The Broad Concept of “Spasticity-Plus Syndrome” in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms
Abstract Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a…
Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions
Abstract Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of patients develop refractory epilepsy (RE) characterized…
Selective Extraction of Cannabinoid Compounds from Cannabis Seed Using Pressurized Hot Water Extraction
Abstract Phytochemicals of Cannabis sativa mainly for the use in the different industries are that of delta-9-tetrahydrocannabinol (THC) and cannabidiol…